Recombinant Porcine CD163
Product Sizes
50 µg
£528.00
32-4404-50UG
About this Product
- SKU:
- 32-4404
- Additional Names:
- CD-163||Hemoglobin scavenger receptor||macrophage-associated antigen||M130||sCD163||CD163||MM130.
- Extra Details:
- Source : Escherichia Coli. CD163 Porcine Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 805 amino acids and having a molecular mass of 87kDa.The CD163 is fused to an 8 amino acid His Tag at C-terminus and purified by proprietary chromatographic techniques. CD163 is an acute phase-regulated receptor which participates in the removal and endocytosis of hemoglobin/haptoglobin complexes by macrophages and thus keeps tissues from free hemoglobin-mediated oxidative damage. Furthermore; CD163 partakes in the uptake and recycling of iron; through endocytosis of hemoglobin/haptoglobin and ensuing breakdown of heme. In addition; CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent way. CD163 demonstrates greater affinity for complexes of hemoglobin and multimeric haptoglobin of HP-1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP-1S phenotype. Moreover; CD163 stimulates a cascade of intracellular signals which involves tyrosine kinase-dependent calcium recruitment; inositol triphosphate formation and secretion of IL-6 & CSF-1.
- Purification:
- "Greater than 95.0% as determined by: (a) Analysis by HPLC. (b) Analysis by SDS-PAGE."
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized CD163 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution CD163 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
