Recombinant Human p53
Product Sizes
5 µg
£686.00
32-4388-5UG
About this Product
- SKU:
- 32-4388
- Additional Names:
- Cellular tumor antigen p53||Tumor suppressor p53||Phosphoprotein p53||Antigen NY-CO-13||TP53||P53||LFS1||TRP53||FLJ92943.
- Extra Details:
- Source : Escherichia Coli. Tumor protein p53 responds to various cellular stresses by regulating target genes that induce cell cycle arrest; apoptosis; senescence; DNA repair; or changes in metabolism. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth; replication; and apoptosis. p53 is a DNA-binding protein containing transcription activation; DNA-binding & oligomerization domains. p53 binds to mdm2; SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. p53 protein is a transcription factor which is encoded in humans by the TP53 gene. Alterations of TP53 occur not only as somatic mutations in human malignancies; but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. p53 mutants that often occur in many different human cancers fail to bind the consensus DNA binding site; and hence cause the loss of tumor suppressor activity. Mutation involving p53 is found in a wide variety of malignant tumors; including breast; ovarian; bladder; colon; lung; and melanoma. The p53 expression in normal cells is low and in an assortment of transformed cell lines is high; which may contribute to transformation and malignancy. Multiple p53 variants encode distinct isoforms; which can regulate p53 transcriptional activity. p53's significance in multicellular organisms is in cell cycle regulation therefore it functions as a tumor suppressor that is involved in preventing cancer. p53's role in conserving stability by preventing genome mutation has earned it descriptions such as 'the guardian of the genome;' 'the guardian angel gene;' and the 'master watchman.''The name p53 refers to its evident molecular mass: it migrates as a 53kDa protein on SDS-PAGE. However; based on calculations from its amino acid residues; p53's mass is in fact only 43.7kDa. This difference is attributed to the high number of proline residues in the protein which slow its migration on SDS-PAGE; consequently making it appear larger than it actually is.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For long term storage store at -20[o]C. Avoid freeze/thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
