Recombinant Human N-Myc Downstream Regulated 1
Product Sizes
50 µg
£528.00
32-4306-50UG
About this Product
- SKU:
- 32-4306
- Additional Names:
- Protein NDRG1||N-myc downstream-regulated gene 1 protein||Differentiation-related gene 1 protein||Reducing agents and tunicamycin-responsive protein||Nickel-specific induction protein Cap43||DRG-1||RTP||Rit42||NDRG1||CAP43||DRG1||GC4||NDR1||NMSL||TDD
- Extra Details:
- Source : Escherichia Coli. NDRG1 Human Recombinant fused with 8 amino acid His tag at C-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 402 amino acids (1-394 a.a.) and having a molecular mass of 43.9 kDa.The NDRG1 is purified by proprietary chromatographic techniques. NDRG1 is a cytoplasmic protein that is involved in stress responses; hormone responses; cell growth; and differentiation. NDRG1 is one of 4 members of the NDRG /-hydrolase family. NDRG1 is classified in databases as a tumor suppressor and heavy metal-response protein. NDRG1's functions include cell-cycle regulation; cellular differentiation; apoptosis; hypoxia response and metal-ion sensing. NDRG1 is also essential for p53-mediated caspase activation and apoptosis. The NDRG1 is a Rab4a effector that is involved in vesicular recycling of E-cadherin. NDRG1 is ubiquitous; it is expressed most notably in placental membranes and prostate; kidney; small intestine; and ovary tissues. NDRG1 has reduced expression in adenocarcinomas compared to normal tissues. NDRG1 gene mutations are reported to be the cause for hereditary motor and sensory neuropathy-Lom (HMSNL); which is a severe autosomal recessive form of Charcot- Marie-Tooth (CMT) disease. In addition; decreased NDRG1 expression in glioma is linked to tumor progression. On the other hand; overexpression of NDRG1 is connected to malignant status of esophageal cancer. NDRG1 may also have a role in portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
