Recombinant Human Myeloid Differentiation Primary Response 88
Product Sizes
20 µg
£528.00
32-4259-20UG
About this Product
- SKU:
- 32-4259
- Additional Names:
- Myeloid differentiation primary response protein MyD88||MYD88||MYD88D.
- Extra Details:
- Source : Escherichia Coli. MYD88 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 345 amino acids (1-309 a.a) and having a molecular mass of 38.7kDa.MYD88 is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Myeloid differentiation primary response gene 88 (MYD88) is a cytosolic adapter protein; which has a central role in the innate and adaptive immune response. MYD88 functions as a vital signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. MYD88 acts via IRAK1; IRAK2; IRF7 and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response. The MYD88 protein increases IL-8 transcription. MYD88 is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1; resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta; NOS2/INOS; and IL12A genes. MYD88 is comprised of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in the MYD88 gene have an increased susceptibility to pyogenic bacterial infections.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
