FHIT; GST Recombinant Protein
Product Sizes
5 µg
£686.00
32-3830-5UG
About this Product
- SKU:
- 32-3830
- Additional Names:
- Bis(5'-adenosyl)-triphosphatase||EC 3.6.1.29||Diadenosine 5';5'''-P1;P3-triphosphate hydrolase||Dinucleosidetriphosphatase||AP3A hydrolase||AP3Aase||Fragile histidine triad protein||FHIT||FRA3B.
- Extra Details:
- Source : Escherichia Coli. FHIT Human Recombinant full length protein expressed in E.coli; shows a 43 kDa band on SDS-PAGE. The FHIT is fused to GST-Tag and purified by proprietary chromatographic techniques. FHIT is a member of the histidine triad gene family. FHIT gene encodes a diadenosine 5';5''-P1;P3-triphosphate hydrolase involved in purine metabolism. FHIT gene includes the common fragile site FRA3B on chromosome 3; where carcinogen-induced damage can lead to translocations and abnormal transcripts of this gene. The FHIT protein is a tumor suppressor with reduced or no expression in numerous types of cancer. FHIT may also act as a tumor suppressor in normal cells. Alterations and deletions of the FHIT (Fragile Histidine Triad) gene are strongly linked to the genesis and establishment of human tumors of the lung; cervix; breast; colon; stomach; and pancreas. The expression of FHIT is more often lost in cancers of individuals with familial mutations causing deficiency in DNA repair genes such as BRCA1; BRCA2 and MSH2. In vitro FHIT functions as a hydrolase that cleaves diadenosine triphosphate (Ap3A) to ADP and AMP. The FHIT -Ap3A enzyme-substrate complex seems to be the tumor suppressor signal. The restoration of FHIT expression in FHIT -deficient cancer cells leads to apoptosis; involving the intrinsic caspase pathway; in cancer-derived cells and in tumor xenografts.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store vial at -20[o]C to -80[o]C. When stored at the recommended temperature; this protein is stable for 12 months.Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
