FADD Recombinant Protein
Product Sizes
10 µg
£528.00
32-3803-10UG
About this Product
- SKU:
- 32-3803
- Additional Names:
- GIG3||MORT1||MGC8528||FADD||Fas (TNFRSF6)-associated via death domain||Protein FADD||FAS-associated death domain protein||FAS-associating death domain-containing protein||Mediator of receptor induced toxicity||Growth-inhibiting gene 3 protein.
- Extra Details:
- Source : Escherichia Coli. FADD produced in E.Coli is a single; non-glycosylated polypeptide chain containing 244 amino acids (1-208 a.a.) and having a molecular mass of 27.4 kDa.FADD is fused to 36 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. FADD is an adaptor protein that cooperates with a variety of cell surface receptors and mediates cell apoptotic signals. Using its C-terminal death domain; FADD is recruited by TNFRSF6/Fas-receptor; tumor necrosis factor receptor; TNFRSF25; and TNFSF10/TRAIL-receptor; and consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of; which allows it to recruit caspase-8; and thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation and cell cycle development. FADD also takes part in cellular sublocalization; protein phosphorylation; and inhibitory molecules.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
