ERO1L Recombinant Protein
Product Sizes
20 µg
£528.00
32-3762-20UG
About this Product
- SKU:
- 32-3762
- Additional Names:
- ERO1-Like (S. Cerevisiae)||Endoplasmic Oxidoreductin-1-Like Protein||Oxidoreductin-1-L-Alpha||ERO1-L-Alpha||ERO1LA||ERO1-L||ERO1 (S. Cerevisiae)-Like||ERO1-Like Protein Alpha||ERO1-Alpha||EC 1.8.4.-||EC 1.8.4||ERO1A||ERO1L.
- Extra Details:
- Source : Escherichia Coli. ERO1L Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 468 amino acids (24-468) and having a molecular mass of 54.4 kDa.ERO1L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. ERO1-like protein alpha (ERO1L) is an essential oxidoreductase; which oxidizes proteins and is necessary for the folding of immunoglobulins. ERO1L covalently binds with PDI (protein disulfide-isomerase) and jointly they generate disulfide bonds between proteins in the endoplasmic reticulum. ERO1L is stimulated by hypoxia; proposing that ERO1L is regulated through the HIF (hypoxia inducible transcrip-tion factor) pathway. At low levels ERO1L is ubiquitously expressed; however at high levels it is expressed in the upper digestive tract and esophagus. In addition; ERO1L is involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae; thus having a role in retrotranslocation of the toxin. Furthermore; ERO1L plays an important role in ER stress-induced; CHOP-dependent apoptosis by activating the inositol 1;4;5-trisphosphate receptor IP3R1.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
