DKK1 Recombinant Protein
Product Sizes
20 µg
£528.00
32-3676-20UG
About this Product
- SKU:
- 32-3676
- Additional Names:
- Dickkopf-related protein 1||Dickkopf-1||Dkk-1||hDkk-1||SK||DKK1||dickkopf WNT signaling pathway inhibitor 1||Dickkopf 1 Homolog||Dickkopf Related Protein-1||Dickkopf-1 Like||Dickkopf-Like Protein 1||Dickkopf (Xenopus Laevis) Homolog 1||DKK-1.
- Extra Details:
- Source : Escherichia Coli. DKK1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 258 amino acids (32-266 a.a) and having a molecular mass of 28.2kDa.DKK1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Dickkopf-related protein 1 (DKK1) antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by creating a ternary complex with the transmembrane protein KREMEN which promotes internalization of LRP5/6. DKKs have a significant role in vertebrate development; where they locally inhibit Wnt controlled processes for instance antero-posterior axial patterning; limb development; somitogenesis and eye formation. Furthermore; Dkks are involved in bone formation and bone disease; cancer and Alzheimer disease in Adults.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
