DAG1 Recombinant Protein
Product Sizes
10 µg
£528.00
32-3649-10UG
About this Product
- SKU:
- 32-3649
- Additional Names:
- Dystroglycan||Dystrophin-associated glycoprotein 1||DAG1||A3a||DAG||AGRNR||156DAG||MDDGC7||MDDGC9.
- Extra Details:
- Source : Escherichia Coli. DAG1 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain (a.a 30-312) containing 293 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 31.87kDa (calculated). Dystroglycan 1 (DAG1) is a laminin binding component of the dystrophin-glycoprotein complex which provides a connection between the subsarcolemmal cytoskeleton and the extracellular matrix. The N-terminal domain of alpha-dystroglycan is secreted into the cerebrospinal fluid. The effect of DAG1 on the nervous system remains vague. The complete dystroglycan complex is expressed in a various tissues and has a role in processes such as laminin and basement membrane assembly; sarcolemmal stability; cell survival; peripheral nerve myelination; nodal structure; cell migration; and epithelial polarization. DAG1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic decrease of DAG1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix; making muscle fibers more susceptible to necrosis.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
