CRABP1 Recombinant Protein
Product Sizes
20 µg
£528.00
32-3588-20UG
About this Product
- SKU:
- 32-3588
- Additional Names:
- Cellular retinoic acid-binding protein 1||Cellular retinoic acid-binding protein I||CRABP-I||CRABP1||RBP5||CRABP||CRABPI.
- Extra Details:
- Source : Escherichia Coli. CRABP1 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 137 amino acids and having a molecular mass of 15.5kDa. The CRABP1 is purified by proprietary chromatographic techniques. CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though; CRABP1 is structurally similar to the cellular retinol-binding proteins; it binds only retinoic acid at specific sites within the nucleus; which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior.Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore; frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma.
- Purification:
- Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- CRABP1 although stable 4[o]C for 4 weeks; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
