COPS7A Recombinant Protein
Product Sizes
20 µg
£528.00
32-3583-20UG
About this Product
- SKU:
- 32-3583
- Additional Names:
- COP9 Signalosome Subunit 7A||COPS7A||Dermal Papilla-Derived Protein 10||CSN7A||SGN7a||JAB1-Containing Signalosome Subunit 7a||COP9 Complex Subunit 7a||COP9 Constitutive Photomorphogenic Homolog Subunit 7A||COP9 Signalosome Complex Subunit 7a||DERP10;
- Extra Details:
- Source : Escherichia Coli. COPS7A Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 298 amino acids (1-275) and having a molecular mass of 32.7 kDa.COPS7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. COP9 Signalosome Subunit 7A (COPS7A) is a component of the COP9 signalosome complex (CSN); a complex involved in a variety of cellular and developmental processes. The CSN complex is a vital regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes; thus leading to decrease in the Ubl ligase activity of SCF-type complexes such as SCF; CSA or DDB2. This complex is also involved in phosphorylation of p53/TP53; JUN; I-kappa-B-alpha/NFKBIA; ITPK1 and IRF8/ICSBP; probably through its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN stimulates and protects degradation by the Ubl system; respectively.
- Purification:
- Greater than 80.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
