CHD4 Recombinant Protein
Product Sizes
20 µg
£528.00
32-3522-20UG
About this Product
- SKU:
- 32-3522
- Additional Names:
- Chromodomain Helicase DNA binding protein 4||Mi-2b||Mi2-BETA||CHD-4||ATP-dependent helicase CHD4||Mi-2 autoantigen 218 kDa protein||EC 3.6.4.12||EC 3.6.1.
- Extra Details:
- Source : Sf9 insect cells. CHD4 is a full-length cDNA coding for the human Mi-2 beta isoform having a molecular mass of 221;298 Dalton (pH 5.8). CHD4 protein is fused to a hexa-histidine purification tag. CHD4 is a member of a family of alleged chromodomain helicase-DNA-binding proteins. Biochemically; CHD4 is a component of the nucleosome transformation and deacetylase (NuRD) complex that takes part in transcription regulation. Autoantibodies targeting the CHD4 are a serologic feature of idiopathic inflammatory myopathies (IIM). In IIM Mi-2 antibodies are characterized by diagnostic sensitivity and specificity of approximately 4-18% and 98-100%; respectively. Moreover; anti-CHD4 antibodies are related to dermatomyositis (frequency up to 31%) and have a great positive predictive value for this type of disease subset. Anti-CHD4 are the only defined myositis-specific autoantibodies clearly focused to a nuclear target. An additional slightly outstanding feature of Mi-2 antibodies relates to their frequency in children; which is similar to that in adults.
- Purification:
- Greater than 95% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
