CDC42 Recombinant Protein
Product Sizes
50 µg
£528.00
32-3492-50UG
About this Product
- SKU:
- 32-3492
- Additional Names:
- Cell division control protein 42 homolog||G25K GTP-binding protein||CDC42||G25K||CDC42Hs.
- Extra Details:
- Source : Escherichia Coli. CDC42 Human Recombinant fused with a 15 amino acid T7 tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 203 amino acids (1-188 a.a.) and having a molecular mass of 22.4kDa.The CDC42 is purified by proprietary chromatographic techniques. CDC42 (Cell division cycle 42 isoform 1) is a small GTPase of the Rho-subfamily that regulates signaling pathways which control various cellular functions including cell morphology; migration; endocytosis and cell cycle progression. CDC42 is a plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In the active state; CDC42 binds to a variety of effector proteins to regulate cellular responses. CDC42 is involved in epithelial cell polarization processes. CDC42 causes the formation of thin; actin-rich surface projections called filopodia. Also; CDC42 regulates actin polymerization through its direct binding to N-WASP (Neural Wiskott-Aldrich syndrome protein); which subsequently activates Arp2/3 complex. Loss of CDC42 function raises endocytotic uptake of apical proteins; as well as apical polarity factors such as Crumbs. The product of oncogene Dbl was described to specifically catalyze the dissociation of GDP from CDC42 protein.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
