BLNK Recombinant Protein
Product Sizes
20 µg
£528.00
32-3339-20UG
About this Product
- SKU:
- 32-3339
- Additional Names:
- B-cell linker protein||B-cell adapter containing a SH2 domain protein||B-cell adapter containing a Src homology 2 domain protein||Cytoplasmic adapter protein||Src homology 2 domain-containing leukocyte protein of 65 kDa||SLP-65||BLNK||BASH||SLP65||AG
- Extra Details:
- Source : Escherichia Coli. BLNK Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 476 amino acids (1-456 a.a.) and having a molecular mass of 52.6kDa (Molecular weight on SDS-PAGE will appear higher). The BLNK is purified by proprietary chromatographic techniques. BLNK is a cytoplasmic linker or adaptor protein which has a significant role in B cell development. B-cell linker (BLNK) is essential for normal B-cell development. BLNK bridges B cell receptor-associated kinase activation with downstream signaling pathways; thus affecting different biological functions. BLNK associates with the effector proteins GRB2; Vav; NCK and PLC-g following activation of the B cell receptor. BLNK is phosphorylated by the Syk tyrosine kinase; which in turn permits activation of downstream effector proteins including GRB2 and PLC-g. Mutations in the BLNK gene cause hypoglobulinemia and absent B cells; a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in the BLNK protein is seen in some cases of pre-B acute lymphoblastic leukemia.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- BLNK should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
