mBID GST Recombinant Protein
Product Sizes
10 µg
£528.00
32-3332-10UG
About this Product
- SKU:
- 32-3332
- Additional Names:
- BH3-interacting domain death agonist||p22 BID||BID||FP497||MGC15319||MGC42355.
- Extra Details:
- Source : Escherichia Coli. BID Mouse Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 1-195 amino acids and having a molecular mass of 48 kDa.The Mouse BID is expressed as GST-Tag fusion protein and purified by proprietary chromatographic technique. BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling; BID interacts with another Bcl-2 family of cell death regulators; called Bax; they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID; and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1; Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
- Purification:
- Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- GST BID although stable at 15[o]C for 1 week; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
