ATXN3 Recombinant Protein
Product Sizes
10 µg
£528.00
32-3273-10UG
About this Product
- SKU:
- 32-3273
- Additional Names:
- Ataxin-3||Machado-Joseph disease protein 1||Spinocerebellar ataxia type 3 protein||ATXN3||ATX3||MJD||MJD1||SCA3||AT3||JOS.
- Extra Details:
- Source : Escherichia Coli. ATXN3 produced in E.Coli is a single; non-glycosylated polypeptide chain containing 370 amino acids (1-370 a.a.) and having a molecular mass of 42.4kDa.ATXN3 is purified by proprietary chromatographic techniques. Ataxin 3 is otherwise known as Machado-Joseph disease protein 1. Machado-Joseph disease is a hereditary autosomal dominant neurodegenerative disorder. ATXN3 contains trinucleotide CAG repeats in the coding region; and the expansion of these repeats from the normal 13-36 to 68-79 causes the Machado-Joseph disease. ATXN3 is a poly-ubiquitin-binding protein whose cellular turnover is regulated by its catalytic activity.In addition; ATXN3 is a proteasome-associated factor which mediates the degradation of ubiquitinated proteins. ATXN3 folds reversibly using a single intermediate; partial destabilization of ATXN3 by chemical denaturation causes the formation of fibrillar aggregates by the non-pathological variant.Ataxin-3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein; p300; and p300/CREB-binding protein-associated factor and hinders transcription by these coactivators.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
