ADAM12 Recombinant Protein
Product Sizes
10 µg
£528.00
32-3157-10UG
About this Product
- SKU:
- 32-3157
- Additional Names:
- Meltrin alpha||MCMP||MLTN||MLTNA||MCMPMltna||ADAM metallopeptidase domain 12||ADAM 12||ADAM12.
- Extra Details:
- Source : Escherichia Coli. ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single; non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa. ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins; and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions; including fertilization; muscle development; and eurogenesis. ADAM12 has 2 alternatively spliced transcripts; a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta; embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration; specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
