TIE-1 Fc Recombinant Protein
Product Sizes
10 µg
£528.00
32-3121-10UG
About this Product
- SKU:
- 32-3121
- Additional Names:
- Tyrosine kinase with immunoglobulin-like and EGF-like domains 1||JTK14||TIE||TIE1.
- Extra Details:
- Source : Insect Cells. Soluble TIE-1 Human Recombinant fused with the Fc part of human IgG1 produced in baculovirus is a homodimeric; glycosylated; polypeptide containing 749 amino acids and having a total molecular mass of 250 kDa. Human TIE-1/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation; the recombinant protein migrates as an approximately 125 kDa protein in SDS-PAGE under reducing conditions.The TIE1 Fc Chimera is purified by proprietary chromatographic techniques. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis; vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide; a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)]; so far no ligand was found for TIE-1.
- Purification:
- Greater than 90.0% as determined by(A)Analysis by RP-HPLC.(B)Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized sTIE-1 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution TIE-1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
