TGFBR2 Recombinant Protein
Product Sizes
10 µg
£528.00
32-3120-10UG
About this Product
- SKU:
- 32-3120
- Additional Names:
- AAT3||FAA3||MFS2||RIIC||LDS1B||LDS2B||TAAD2||TGFR-2||TGFbeta-RII||TGFBR-2||TGF-beta receptor type-2||Transforming growth factor-beta receptor type II||TGF-beta receptor type II||TGF-beta type II receptor||TbetaR-II||TGFBR2.
- Extra Details:
- Source : Escherichia Coli. TGFBR2 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain encoding 133 amino acids (27-159 a.a.); the extracellular domain of TGFBR2; having a molecular mass of 15.1 kDa.TGFBR2 is purified by proprietary chromatographic techniques TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain; forms a heterodimeric complex with another receptor protein; and binds TGF-beta. This receptor/ligand complex phosphorylates proteins; which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome; Loeys-Deitz Aortic Aneurysm Syndrome; and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer.
- Purification:
- Greater than 97.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized TGFBR2 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution TGFBR2 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
