AURKB Recombinant Protein
Product Sizes
10 µg
£528.00
32-2946-10UG
About this Product
- SKU:
- 32-2946
- Additional Names:
- Serine/threonine-protein kinase 12||Aurora kinase B||Serine/threonine-protein kinase aurora-B||Aurora- and Ipl1-like midbody-associated protein 1||Aurora/IPL1-related kinase 2||Aurora-related kinase 2||AIM-1||ARK-2||STK-1||AURKB||AIK2||AIM1||ARK2||ST
- Extra Details:
- Source : Escherichia Coli. AURKB Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 364 amino acids (1-344) and having a molecular mass of 41.4kDa. AURKB is fused to 20 a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques. Aurora Kinase B (AURKB) belongs to a family of mitotic serine/threonine kinases. AURKB connects with chromosomes for the period of prophase prior to relocalizing to the spindle at anaphase. AURKB localizes to microtubules near kinetochores; specifically to the specialized microtubules called K-fibers. AURKB controls chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. AURKB is required for kinetochore localization of BUB1 and SGOL1. AURKB expression during the G2/M phase transition is firmly coordinated with histone H3 phosphorylation; while overexpression is seen in many kinds of cancers. AURKB phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. AURKB is a component of the CPC (chromosomal passenger complex); which is a complex that acts as a key regulator of mitosis. High level expression of AURKB is seen in the thymus; which is also expressed in the spleen; lung; testis; colon; placenta and fetal liver. AURKB is expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- AURKB although stable at 4[o]C for 1 week; should be stored below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
