tPA Recombinant Protein
Product Sizes
100 µg
£631.00
32-2858-100UG
About this Product
- SKU:
- 32-2858
- Additional Names:
- Tissue-type plasminogen activator||EC 3.4.21.68||tPA||t-PA||t-plasminogen activator||TPA||T-PA||DKFZp686I03148.
- Extra Details:
- Source : Chinese Hamster Ovary Cells (CHO) Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder. Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single; glycosylated polypeptide chain containing 527 amino acids and having a molecular mass of 59008.71 Dalton. tPA is a serine protease enzyme that converts plasminogen to plasmin. The tPA is purified by proprietary chromatographic techniques. Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin; a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin.This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis; which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism.
- Purification:
- Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized t-PA although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution tPA should be stored at 4[o]C between 2-7 days and for future use below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
