TIMP1 HEK Recombinant Protein
Product Sizes
10 µg
£528.00
32-2850-10UG
About this Product
- SKU:
- 32-2850
- Additional Names:
- Metalloproteinase inhibitor 1||Tissue inhibitor of metalloproteinases||TIMP-1||Erythroid-potentiating activity||EPA||Fibroblast collagenase inhibitor||Collagenase inhibitor||TIMP1||CLGI||TIMP||EPO||HCI||FLJ90373.
- Extra Details:
- Source : HEK293 Cells. TIMP1 Human Recombinant produced in HEK-293 cells is a secreted protein with the sequence of Human TIMP-1 (amino acids Cys24-Ala207) and fused to a polyhistidine tag at the C-terminus. TIMP1 is a member of the TIMP family. TIMP1 is an inducible glycoprotein produced by various cell types. The TIMP1 glycoprotein is a natural inhibitor of the matrix metalloproteinases; which a group of peptidases involved in degradation of the extracellular matrix. TIMP1 binds in a reversible mode to MMPs; with regions in the N-terminal domain binding to the MMP substrate-binding site. On top of its inhibitory function against most of the known MMPs; TIMP1 is able to promote cell proliferation in a broad range of cell types; and may also have an anti-apoptotic role. Furthermore; TIMP1 has erthyroid-potentiating activity via translocation to the nucleus and also inhibits apoptosis in B-cells. The TIMP1 gene is situated within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 activity is dependent on the existence of disulfide bonds. TIMP1 transcription is extremely inducible in reaction to many cytokines and hormones.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Lyophilized TIMP1 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution TIMP1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
