TGM2 Recombinant Protein
Product Sizes
20 µg
£528.00
32-2845-20UG
About this Product
- SKU:
- 32-2845
- Additional Names:
- Protein-glutamine gamma-glutamyltransferase 2||EC 2.3.2.13||Tissue transglutaminase||TGase C||TGC||TG(C)||Transglutaminase-2||TGase-H||TG2||TGM2.
- Extra Details:
- Source : Escherichia Coli. Tissue Transglutaminase Human Recombinant produced in E.coli is a non-glycosylated; polypeptide chain having a molecular mass of 78;018 Dalton. tTG is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. By point mutation of the active center the catalytic transglutaminase activity has been eliminated; resulting in increased stability during storage and coating. Celiac disease is an enteropathy that is characterized by intestinal lesions of variable severity. Tissue-type transglutaminase (tTG) is believed to be the predominant autoantigen for celiac disease and the corresponding autoantibodies show higher sensitivity and specificity than anti-gliadin antibodies. Highly pure recombinant human tTG is now available to replace the traditionally used tTG fraction from guinea pig.Tissue-type transglutaminase antigens have been specifically modified for improved handling: exchange of an active site amino acid eliminates the protein cross-linking activity of the enzyme; while maintaining the native three-dimensional structure and the enzyme's secondary GTPase activity. This engineering assures reproducible properties of the antigen preparations through the absence of variable and ill-defined covalent aggregates of tTG antigen and host cell proteins.
- Purification:
- Greater than 95% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
