SAT1 Recombinant Protein
Product Sizes
20 µg
£528.00
32-2800-20UG
About this Product
- SKU:
- 32-2800
- Additional Names:
- Diamine acetyltransferase 1||Spermidine/spermine N(1)-acetyltransferase 1||Putrescine acetyltransferase||Polyamine N-acetyltransferase 1||SSAT-1||SSAT||SAT1||SAT||DC21||KFSD||KFSDX.
- Extra Details:
- Source : Escherichia Coli. SAT1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 191 amino acids (1-171 a.a.) and having a molecular mass of 22.1kDa.The SAT1 is purified by proprietary chromatographic techniques. SAT-1 is a member the acetyltransferase family; and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. SAT1 catalyzes the acetylation of spermidine and spermine; and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Therefore; SAT-1's role is essential in polyamine homoeostasis; given that acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. Increased SAT1 activity causes variety of other effects which include pancreatic cells death; obstruction of regenerative tissue growth; behavioral changes; keratosis follicularis spinulosa decalvans (KFSD); and hair loss.Defects in the SAT1 gene are linked to KFSD (keratosis follicularis spinulosa decalvans); which is a rare X-linked disorder affecting the skin and the eye. The KFSD affected men show thickening of the skin of the neck; ears; and extremities; particularly the palms and soles; loss of eyebrows; eyelashes and beard; thickening of the eyelids with blepharitis and ectropion; and corneal degeneration. Even though the majority of the affected families are compatible with an X-linked inheritance; KFSD are found to be clinically and genetically heterogeneous.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
