PIN1 Recombinant Protein
Product Sizes
20 µg
£528.00
32-2671-20UG
About this Product
- SKU:
- 32-2671
- Additional Names:
- Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1||EC 5.2.1.8||Rotamase Pin1||PPIase Pin1||DOD||UBL5||PIN1||PPIase.
- Extra Details:
- Source : Escherichia Coli. PPIase Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 163 amino acids & having a molecular mass of 18.2 kDa. The PIN1 is purified by proprietary chromatographic techniques. Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain; and is structurally and functionally related to Ess1/Ptf1; an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA; PLK I; Wee; and Myt1 kinases); several transcription factors like b-Catenin; c-Jun; and the tumor suppressor protein p53; and some specific proteins like the RNA Pol II; the cytoskeleton protein tau; and the G1/S protein Cyclin D1.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
