PARP1 Recombinant Protein
Product Sizes
25 µg
£528.00
32-2644-25UG
About this Product
- SKU:
- 32-2644
- Additional Names:
- ADPRT||ADPRT1||pADPRT||pADPRT-1||PARP||PARP-1||PPOL||Poly [ADP-ribose] polymerase 1||NAD(+) ADP-ribosyltransferase 1||Poly[ADP-ribose] synthase 1||PARP1.
- Extra Details:
- Source : Escherichia Coli. PARP1 Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 354 amino acids (662-1014a.a.) and having a molecular mass of 39.6 kDa. PARP1 is purified by proprietary chromatographic techniques. PARP1 takes part in the base excision repair pathway; by catalyzing the poly ADP-ribosyl of a restricted number of acceptor proteins involved in chromatin architecture and in DNA metabolism.. PARP1 mediates the poly ADP-ribosy of APLF and CHFR. PARP1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. PARP1 is a chromatin-associated enzyme; poly (ADP-ribosyl) transferase; which modifies various nuclear proteins by poly ADP-ribosyl. PARP1 takes part in the regulation of various significant cellular processes such as differentiation; proliferation; and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. PARP1 is a site of mutation in Fanconi anemia; and is involved in the pathophysiology of type I diabetes.
- Purification:
- Greater than 95% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- PARP1 Human Recombinant although stable at 4[o]C for 1 week; should be stored below -18[o]C. Please prevent freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
