NUDT1 Recombinant Protein
Product Sizes
20 µg
£528.00
32-2619-20UG
About this Product
- SKU:
- 32-2619
- Additional Names:
- 7;8-dihydro-8-oxoguanine triphosphatase||8-oxo-dGTPase||Nucleoside diphosphate-linked moiety X motif 1||Nudix motif 1||NUDT1||MTH1.
- Extra Details:
- Source : Escherichia Coli. NUDT1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 176 amino acids (1-156 a.a.) and having a molecular mass of 20.1kDa. The NUDT1 is purified by proprietary chromatographic techniques. NUDT1 is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates; such as 8-oxo-dGTP; 8-oxo-dATP; 2-hydroxy-dATP; and 2-hydroxy rATP; to monophosphates; thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. NUDT1 is found mostly in the cytoplasm; with some in the mitochondria; suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Moreover; NUDT1 is expressed at much higher levels in proliferating cells than in resting cells. Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations which may result in carcinogenesis or neurodegeneration.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- NUDT1 should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
