NEDD8 Recombinant Protein
Product Sizes
25 µg
£528.00
32-2601-25UG
About this Product
- SKU:
- 32-2601
- Additional Names:
- Nedd-8||FLJ43224||MGC104393||MGC125896||MGC125897||NEDD8||Ubiquitin-like protein Nedd8||Neddylin||Neural precursor cell expressed developmentally down-regulated protein 8.
- Extra Details:
- Source : Escherichia Coli. NEDD8 Human Recombinant fused with 37 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 113 amino acids (1-76 a.a.) and having a molecular mass of 12.8 kDa.The NEDD8 is purified by proprietary chromatographic techniques. NEDD8 is part of the ubiquitin family. Human NEDD8 shares 60% amino acid sequence homology to ubiquitin. The NEDD8 system is essential for the regulation of protein degradation pathways involved in cell cycle progression; morphogenesis and tumorigenesis. NEDD8 is involved in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E-1 complex UbE1c- appbp1 and linkage to the E-2 enzyme UbE2m. Attachment of NEDD8 to cullins activates their associated E-3 ubiquitin ligase activity; and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- NEDD8 although stable 4[o]C for 4 weeks; should be stored desiccated below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
