MMP 9 Recombinant Protein
Product Sizes
10 µg
£528.00
32-2554-10UG
About this Product
- SKU:
- 32-2554
- Additional Names:
- Matrix metalloproteinase-9||MMP-9||92 kDa type IV collagenase||92 kDa gelatinase||Gelatinase B||GELB||MMP9||CLG4B.
- Extra Details:
- Source : Escherichia Coli. MMP-9 Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 338 amino acids fragment (113-450) corresponding to the catalytic domain of the protein; having a total molecular mass of 42.03kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The MMP-9 is purified by proprietary chromatographic techniques. Matrix metalloproteinases are a family of zinc and calcium-dependent endopeptidases that break down extracellular matrix proteins. The MMP9 is secreted as a 92kDa zymogen. Cleavage of ProMMP-9 results in the active enzyme; having a molecular weight of approximately 82kDa. MMP9 is composed of the following domains: a gelatin-binding domain consisting of three fibronectin type II units; a catalytic domain containing the zinc-binding site; a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by the several cell types: monocytes; macrophages; neutrophils; keratinocytes; fibroblasts; osteoclasts and endothelial cells. MMP9 is involved in inflammatory responses; tissue remodeling; wound healing; tumor growth and metastasis. MMP9 may also play an important part in local proteolysis of the extracellular matrix and in leukocyte migration; as well as in bone osteoclastic resorption. MMP9 cleaves type IV and type V collagens into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. MMP9 can also degrade fibronectin but not laminin or Pz-peptide.MMP9 defects may be a cause of susceptibility to intervertebral disc disease (IDD); also known as lumbar disk herniation (LDH).
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. Please avoid freeze thaw cycles.
- Supplier:
- Abeomics
- Type:
- Assay Kits:MMP
- Manufacturer's Data Sheet:1.jpg
