MMP 2 HEK Recombinant Protein
Product Sizes
10 µg
£528.00
32-2546-10UG
About this Product
- SKU:
- 32-2546
- Additional Names:
- 72 kDa type IV collagenase||72 kDa gelatinase||Gelatinase A||Matrix metalloproteinase-2||MMP-2||TBE-1||MMP2||CLG4A||CLG4||MONA||MMP-II.
- Extra Details:
- Source : HEK293 cells. MMP-2 Human Recombinant produced in HEK293 cells is a proform of the Human MMP-2 (Ala30-Cys660) and fused with a ployhistide tag at the C-terminus; having an Mw of 71kDa. MMP-2 is purified by proprietary chromatographic techniques. Matrix metalloproteinase-2 (MMP-2) is a type IV collagenase; which is involved in endometrial menstrual breakdown; regulation of vascularization and the inflammatory response. MMP-2 contains a number of distinct domains: a prodomain that is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin like domain believed to have a role in substrate targeting; and a carboxyl terminal (hemopexin like) domain containing 2 N-linked glycosylation. The MMP-2 can degrade an extensive array of substrates including type IV; V; VII and X collagens as well as gelatin type I. In addition; MMP-2 interacts with THBS2; TIMP2; Thrombospondin 1; CCL7 and TIMP4. MMP-2 autocatalytic cleavage in the C-terminal generates the anti-angiogenic peptide; PEX. This process seems to be made possible by binding integrinv/beta3. Defects in the MMP-2 are the cause of Torg-Winchester syndrome (TWS); aka multicentric osteolysis nodulosis and arthropathy (MONA).
- Purification:
- Greater than 95% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store MMP-2 at 4[o]C if entire vial will be used within 2-4 weeks. Store frozen at -20[o]C for longer periods of time.Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Assay Kits:MMP
- Manufacturer's Data Sheet:1.jpg
