MAT2A Recombinant Protein
Product Sizes
20 µg
£528.00
32-2522-20UG
About this Product
- SKU:
- 32-2522
- Additional Names:
- MATA2||MATII||SAMS2||MAT-2A||S-adenosylmethionine synthetase isoform type-2||AdoMet synthetase 2||Methionine adenosyltransferase 2||Methionine adenosyltransferase II||MAT2A||AMS2.
- Extra Details:
- Source : Escherichia Coli. MAT2A Human Recombinant fused with His tag (20 a.a.) at C-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 415 amino acids and having a molecular mass of 45.8 kDa.The MAT2A is purified by proprietary chromatographic techniques. MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver; MAT2A expression associates with growth; dedifferentiation; and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- MAT2A although stable 4[o]C for 4 weeks; should be stored desiccated below -18[o]C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
