IMPDH2 Recombinant Protein
Product Sizes
10 µg
£528.00
32-2472-10UG
About this Product
- SKU:
- 32-2472
- Additional Names:
- Inosine-5'-monophosphate dehydrogenase 2||IMP dehydrogenase 2||IMPD 2||IMPDH 2||IMPDH-II||IMPDH2||IMPD2.
- Extra Details:
- Source : E.coli. IMPDH2 Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 534 amino acids (1-514) and having a molecular mass of 58kDa.IMPDH2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. IMPDH2 is a member of the IMPDH/GMPR family. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate; which is afterward converted into guanosine-5'-monophosphate. IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. IMPDH2 is consequently involved in maintaining cellular guanine deoxy- and ribonucleotide pools required for DNA and RNA synthesis. In addition; IMPDH1 and IMPDH2 are targets for the important immunosuppressive drug; mycophenolic acid (MPA). Furthermore; the IMPDH2 gene is up-regulated in some neoplasms; suggesting it may have a role in malignant transformation.
- Purification:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
