IDE Recombinant Protein
Product Sizes
10 µg
£528.00
32-2460-10UG
About this Product
- SKU:
- 32-2460
- Additional Names:
- Insulin-Degrading Enzyme||Abeta-Degrading Protease||Insulin Protease||EC 3.4.24.56||Insulinase||INSULYSIN||Insulysin||EC 3.4.24||IDE.
- Extra Details:
- Source : Escherichia Coli. IDE Human Recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain (Met1-Leu1019) containing 1026 amino acids including a 7 aa His tag at C-terminus. The total calculated molecular mass is 119kDa. Insulin-Degrading Enzyme (IDE) is a zinc metallopeptidase which degrades intracellular insulin; and thus terminates insulins activity; as well as playing a part in intercellular peptide signaling by degrading various peptides such as glucagon; amylin; bradykinin; and kallidin. The preferential affinity of the IDE enzyme for insulin results in insulin-mediated inhibition of the degradation of additional peptides such as beta-amyloid. Deficiencies in IDE protein's function are linked with Alzheimer's disease and type 2 diabetes mellitus nevertheless mutations in the IDE gene have not been demonstrated to be causative for these diseases. Insulin-Degrading Enzyme localizes mainly to the cytoplasm however in some cell types it localizes to the extracellular space; cell membrane; peroxisome; and mitochondrion. In addition; IDE degrades amyloid formed by APP and IAPP. Furthermore; IDE plays a part in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
