HPD Recombinant Protein
Product Sizes
10 µg
£528.00
32-2447-10UG
About this Product
- SKU:
- 32-2447
- Additional Names:
- 4HPPD||GLOD3||4-HPPD||PPD||HPPDase||Glyoxalase Domain Containing 3||4-HydroxyphenylpYruvate Dioxygenase.
- Extra Details:
- Source : Escherichia Coli. HPD produced in E.Coli is a single; non-glycosylated polypeptide chain containing 413 amino acids (1-393a.a.) and having a molecular mass of 47kDa.HPD is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. 4-Hydroxyphenylpyruvate Dioxygenase Isoform-1 is an Fe-containing enzyme; which catalyzes the second reaction in the catabolism of tyrosine the conversion of 4-hydroxyphenylpyruvate to homogentisate. Present as a homodimer; HPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Flaws in the gene encoding HPD result in tyrosinemia type 3 and hawkinsinuria; two inborn defects of metabolism which are related to a number of symptoms; like mental retardation and seizures and hair and urine abnormalities.
- Purification:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
