DNMT3L Recombinant Protein
Product Sizes
10 µg
£528.00
32-2279-10UG
About this Product
- SKU:
- 32-2279
- Additional Names:
- DNMT3L||DNA (Cytosine-5-)-Methyltransferase 3-Like||Human Cytosine-5-Methyltransferase 3-Like Protein 11||Cytosine-5-Methyltransferase 3-Like Protein||DNA (Cytosine-5)-Methyltransferase 3-Like.
- Extra Details:
- Source : Escherichia Coli. DNMT3L Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 411 amino acids (1-386) and having a molecular mass of 46.2kDa.DNMT3L is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. DNA Cytosine-5--Methyltransferase 3-Like (DNMT3L) is a nuclear protein with similarity to DNA methyltransferases; but is not believed to act as a DNA methyltransferase since it doesn't contain the amino acid residues needed for methyltransferase activity. Nevertheless; DNMT3L stimulates de novo methylation by DNA cytosine methyltransferase 3 alpha and is assumed to be required for the formation of maternal genomic imprints. DNMT3L also mediates transcriptional repression as a result of interaction with histone deacetylase 1. DNMT3L is a catalytically inactive regulatory factor of DNA methyltransferases; which is vital for the function of DNMT3A and DNMT3B. DNMT3L activates DNMT3A and DNMT3B by binding to their catalytic domain. Furthermore; DNMT3L accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
