CASP3 Recombinant Protein
Product Sizes
10 µg
£528.00
32-2208-10UG
About this Product
- SKU:
- 32-2208
- Additional Names:
- Caspase 3 Apoptosis-Related Cysteine Peptidase||CPP32 Caspase 3 Apoptosis-Related Cysteine Protease||Cysteine Protease CPP32||Protein Yama||CASP-3||CPP-32||SCA-1||SREBP Cleavage Activity 1||EC 3.4.22.56||CPP32B||caspase-3||PARP Cleavage Protease||pro
- Extra Details:
- Source : Escherichia Coli. CASP3 Human Recombinant produced in E.coli is a single; non-glycosylated polypeptide chain containing 103 amino acids (176-277) and having a molecular mass of 12kDa.CASP3 is purified by proprietary chromatographic techniques. Caspase 3 Apoptosis-Related Cysteine Peptidase (CASP3) belongs to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a key role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to generate 2 subunits; large and small; that dimerize to create the active enzyme. CASP3 protein cleaves and activates caspases 6; 7 and 9; and the protein itself is processed by caspases 8; 9 and 10. CASP3 is the leading caspase involved in the cleavage of amyloid-beta 4A precursor protein; which is linked with neuronal death in Alzheimer's disease. In addition; CASP3 is involved in the cleavage of huntingtin. CASP3 also cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. CASP3 initiates cell adhesion in sympathetic neurons through RET cleavage.
- Purification:
- Greater than 80.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
