ALDH5A1 Recombinant Protein
Product Sizes
10 µg
£528.00
32-2145-10UG
About this Product
- SKU:
- 32-2145
- Additional Names:
- Succinate-semialdehyde dehydrogenase mitochondrial||Aldehyde dehydrogenase family 5 member A1||NAD(+)-dependent succinic semialdehyde dehydrogenase||ALDH5A1||SSADH||SSDH.
- Extra Details:
- Source : Escherichia Coli. ALDH5A1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 509 amino acids (48-535 a.a.) and having a molecular mass of 54.6kDa. The ALDH5A1 is purified by proprietary chromatographic techniques. ALDH5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase; which is a member of the aldehyde dehydrogenase family of proteins. The ALDH5A1 protein functions as a mediator to the NADP+-dependent oxidation of aldehydes into acids and has an imperative role in the detoxification of alcohol-derived acetaldehyde; as well as in lipid peroxidation and in the metabolism of corticosteroids; biogenic amines and neurotransmitters. ALDH5A1 is expressed in various tissues; including the liver; heart; lung; brain; kidney and placenta. Deficiency in the ALDH5A1 enzyme; known as 4-hydroxybutyricaciduria; is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to this defect; physiologic fluids from patients accumulate GHB; which is a compound with numerous neuromodulatory properties.
- Purification:
- Greater than 90.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
