AKR1B1 Recombinant Protein
Product Sizes
50 µg
£528.00
32-2133-50UG
About this Product
- SKU:
- 32-2133
- Additional Names:
- Aldehyde Reductase||EC 1.1.1.21||ALR2||ALDR1||MGC1804||Aldo-keto reductase family1 member B1||Aldose Reductase||AKR1B1||AR||ADR.
- Extra Details:
- Source : Escherichia Coli. AKR1B1 Human Recombinant amino produced in E.Coli is a single; non-glycosylated polypeptide chain containing 316 amino acids having a molecular mass of 35.8 kDa.The AKR1B1 is purified by proprietary chromatographic techniques. AKR1B1 is part of the aldo/keto reductase superfamily; which consists of more than 40 known enzymes and proteins. AKR1B1 catalyzes the reduction several aldehydes; including the aldehyde form of glucose; and thus involved in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. AKR1B1 catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Transgenic mice over expressing human aldose reductase show that AKR1B1 is a key player in ischemic injury and impairment of functional and metabolic recovery after ischemia. Aldose Reductase is an obligatory mediator of TNF-alpha signaling leading to an increase in the expression of adhesion molecules and increased binding of monocytes to the endothelium. AKR1B1 is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells.
- Purification:
- Greater than 95.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
