TARC His Recombinant Protein
Product Sizes
10 µg
£528.00
32-2000-10UG
About this Product
- SKU:
- 32-2000
- Additional Names:
- C-C motif chemokine 17||Small-inducible cytokine A17||Thymus and activation-regulated chemokine||CC chemokine TARC||ABCD-2||CCL17||CCL-17||SCYA17||TARC||A-152E5.3||MGC138271||MGC138273.
- Extra Details:
- Source : Escherichia Coli. TARC Human Recombinant produced in E.Coli is a non-glycosylated; Polypeptide chain containing 92 amino acids (24-94 a.a.) and having a molecular mass of 10.3 kDa. The TARC is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members; CCL-17 has approximately 24-29% amino acid sequence identity with RANTES; MIP-1a; MIP-1b; MCP-1; MCP-2; MCP-3 and I-309. TARC is expressed in thymus; and at a lower level in the lung; colon; and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4; a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes; but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
- Purification:
- Greater than 95% as determined by Analysis by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
