IL-2 Superkine (Fc) [IL-2 (human):Fc (human) (Recombinant)]
Product Sizes
10 µg
£506.00
32-190051-10UG
About this Product
- SKU:
- 32-190051
- Additional Names:
- IL-2 Superkine (human):Fc (human) (rec.); Interleukin-2; T Cell Growth Factor; TCGF; Aldesleukin; Super-2
- Extra Details:
- Source :HEK 293 cells Specific Binds to human and mouse IL-2R.Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells; natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells; activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover; studies have shown that IL-2 is required for activation-induced apoptosis; an important homeostatic mechanism in the immune system; which is involved in the maintenance of peripheral tolerance to self-antigens. IL-2 promotes T cell proliferation and particularly naive T cells. IL-2 signaling on activated T cells is effected through a quaternary high-affinity receptor complex consisting of IL-2; IL-2Ralpha (CD25); IL-2Rbeta and IL-2Rgamma. Naive T cells are relatively insensitive to IL-2 as they only express small amounts of IL-2Rbeta and IL-2Rgamma. They only acquire sensitivity after CD25 expression; which captures the cytokine and presents it to the IL-2Rbeta and IL-2Rgamma receptors. IL-2 Superkine (Fc) is an artificial variant of IL-2 containing mutations at positions L80F / R81D / L85V / I 86V / I92F. These mutations are located in the molecule's core that acts to stabilize the structure and to give it a receptor-binding conformation mimicking native IL-2 bound to CD25. These mutations effectively eliminate the functional requirement of IL-2 for CD25 expression and elicit proliferation of T cells. Compared to IL-2; the IL-2 superkine induces superior expansion of cytotoxic T cells; leading to improved antitumour responses in vivo; and elicits proportionally less toxicity by lowering the expansion of Tregulatory cells and reducing pulmonary oedema.
- Purification:
- >=95% (SDS-PAGE)
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Short Term Storage +4[o]C ; Long Term Storage-20[o]C ;After reconstitution; prepare aliquots and store at -20[o]C. Avoid freeze/thaw cycles. PBS containing at least 0. 1% BSA should be used for further dilutions. Stable for at least 6 months after receipt when stored at -20[o]C. Working aliquots are stable for up to 3 months when stored at -20[o]C.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:1.jpg
