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Proteins and Peptides

IL-10 (human):Fc (human) (Recombinant) (non-lytic)

Product Sizes
10 µg
£546.00
32-190045-10UG
50 µg
£709.00
32-190045-50UG
About this Product
SKU:
32-190045
Additional Names:
Interleukin-10; Cytokine Sythesis Inhibitory Factor; CSIF
Extra Details:
Source :CHO cells Specific Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells; B cells; keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells; natural killer cells and monocytes/macrophages. Several studies have suggest the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.Other Product Data Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
Purification:
>=98% (SDS-PAGE)
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Short Term Storage +4[o]C ; Long Term Storage-20[o]C ; Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -20[o]C. Working aliquots are stable for up to 3 months when stored at -20[o]C.
Supplier:
Abeomics
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
Figure 1: The biological activity of IL-10 (human):Fc (human) (rec.) (non-lytic) (#CHI-HF-22010) has been measured in a cell proliferation assay using MC/9-2 mouse mast cells. The ED50 is 1.1-1.7ng/ml for this human IL-10 using MC/9 cells.