Mouse TREM2 Protein; hFc Tag
Product Sizes
50 µg
£634.00
32-18524-50UG
100 µg
£750.00
32-18524-100UG
About this Product
- SKU:
- 32-18524
- Additional Names:
- TREM-2;Trem2a;Trem2b;Trem2c
- Extra Details:
- Description :Recombinant mouse TREM2 protein with C-terminal human Fc tagBackground: The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors; such as kinases and phospholipase C-gamma; to form a receptor signaling complex that activates myeloid cells; including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq; Jan 2013]Description: Recombinant mouse TREM2 protein with C-terminal human Fc tagMolecular Characterization: Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330)Molecular Weight :The protein has a predicted molecular mass of 42.9 kDa after removal of the signal peptide.Tag :C-Human Fc Tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
