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Canine PD-1 Protein; mFc Tag

Product Sizes
50 µg
£788.00
32-18514-50UG
100 µg
£980.00
32-18514-100UG
About this Product
SKU:
32-18514
Additional Names:
CD279; PD-1; PD1; SLEB2; hPD-1; hPD-l; hSLE1
Extra Details:
Description :Recombinant Canine PD-1 protein with C-terminal mouse Fc tag Background : Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions; including those of effector CD8 T cells. In addition; this protein can also promote the differentiation of CD4 T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas; and has demonstrated to play a role in anti-tumor immunity. Moreover; this protein has been shown to be involved in safeguarding against autoimmunity; however; it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. Molecular Characterization: mass of 42.4 kDa after removal of the signal peptide. The apparent molecular mass of dPD-1-mFc is approximately 55-70 kDa due to glycosylation. Tag :C-Mouse Fc tag
Host:
HEK293
Purification:
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:
Abeomics
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules
  • Manufacturer's Data Sheet:1.jpg
Figure 2. ELISA plate pre-coated by 2 µg/mL (100 µL/well) Canine PD-1 Protein; mFc Tag can bind Anti-Canine PD-1(INTERVET 4F12) mAb in a linear range of 0.64-80 ng/mL.
Figure 3. ELISA plate pre-coated by 2 µg/mL (100 µL/well) Canine PD-1 Protein; mFc Tag can bind Canine PD-L1 Protein; hFc Tag in a linear range of 16-2000 ng/mL.
Figure 4. Flow cytometry analysis with 1µg/mL Canine PD-1 Protein; mFc Tag on Expi293 cells transfected with Canine PD-L1 protein (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 4. Flow cytometry analysis with 1µg/mL Canine PD-1 Protein; mFc Tag on Expi293 cells transfected with Canine PD-L1 protein (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).