Human CD209 Protein; His Tag
Product Sizes
50 µg
£702.00
32-18415-50UG
100 µg
£849.00
32-18415-100UG
About this Product
- SKU:
- 32-18415
- Additional Names:
- CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN
- Extra Details:
- Description :Recombinant human CD209 Protein with N-terminal6Ã-His tagBackground : This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health; including leprosy and tuberculosis mycobacteria; the Ebola; hepatitis C; HIV-1 and Dengue viruses; and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain; a flexible tandem-repeat neck domain; a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene; CLEC4M (Gene ID: 10332); also known as L-SIGN. The two genes differ in viral recognition and expression patterns; with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection; while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease; including rs4804803; which is associated with SARS severity. Molecular Characterization: mass of 40.3 kDa after removal of the signal peptide. The apparent molecular mass of His-CD209 is approximately 35-55 kDa due to glycosylation.Tag :N-6×His tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
