Human ADAM17(581-642) Protein; mFc Tag
Product Sizes
50 µg
£621.00
32-18397-50UG
100 µg
£731.00
32-18397-100UG
About this Product
- SKU:
- 32-18397
- Additional Names:
- CSVP; TACE; CD156B; NISBD1
- Extra Details:
- Description :Recombinant human ADAM17(581-642) Protein with C-terminal mouse Fc tagBackground: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins; and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions; including fertilization; muscle development; and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha; in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates; including cell adhesion proteins; cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands; and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis; rheumatoid arthritis; multiple sclerosis and Crohn's disease patients; suggesting that the encoded protein may play a role in autoimmune disease. Additionally; this protease may play a role in viral infection through its cleavage of ACE2; the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq; Aug 2020]Description: Recombinant human ADAM17(581-642) Protein with C-terminal mouse Fc tagMolecular Characterization: ADAM17(Phe581-Glu642) mFc(Pro99-Lys330)Molecular Weight :The protein has a predicted molecular mass of 33.2 kDa after removal of the signal peptide. The apparent molecular mass of ADAM17(581-642)-mFc is approximately 35-55 kDa due to glycosylation.Tag :C-mouse Fc tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
