Human CGRPR and RAMP1 Heterodimer Protein; hFc Tag and mFc Tag
Product Sizes
50 µg
£702.00
32-18383-50UG
100 µg
£849.00
32-18383-100UG
About this Product
- SKU:
- 32-18383
- Additional Names:
- CRLR; CGRPR; LMPHM8 and RAMP1
- Extra Details:
- Description :Recombinant human CGRPR protein with C-terminal human Fc tag and human RAMP1 protein with C-terminal mouse Fc tagBackground : The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs); is expressed throughout the trigeminal system; including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces; thereby blocking CGRP activity.Molecular Characterization: mass of 39.9 and 36.7 kDa after removal of the signal peptide. The apparent molecular mass of CGRPR-hFc and RAMP1-mFc is approximately 35-70 kDa due to glycosylation.Tag :C-Human Fc tag and C-mouse Fc tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
