Human ITGAV and ITGB6 Heterodimer Protein; His Tag and hFc Tag
Product Sizes
50 µg
£654.00
32-18365-50UG
100 µg
£781.00
32-18365-100UG
About this Product
- SKU:
- 32-18365
- Additional Names:
- CD51; MSK8; VNRA; VTNR and AI1H
- Extra Details:
- Description :Recombinant human ITGAV protein with C-terminal6Ã-His tag and human ITGB6 protein with C-terminal human Fc tagBackground : Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also; Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore; it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin; and is enhanced by PAR-1.Molecular Characterization: mass of 107.1 and 100.4 kDa after removal of the signal peptide. The apparent molecular mass of ITGAV-His abd ITGB6-hFc is approximately 130-250 kDa due to glycosylation.Tag :C-6×His tag and C-Human Fc tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
