Human APO-1 Protein; hFc Tag
Product Sizes
50 µg
£621.00
32-18344-50UG
100 µg
£731.00
32-18344-100UG
About this Product
- SKU:
- 32-18344
- Additional Names:
- APT1; CD95; FAS1; FAS; FASTM; ALPS1A; TNFRSF6
- Extra Details:
- Description :Recombinant human APO-1 Protein with C-terminal human Fc tagBackground : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death; and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD); caspase 8; and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade; and leads to apoptosis. This receptor has been also shown to activate NF-kappaB; MAPK3/ERK1; and MAPK8/JNK; and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described; some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. Molecular Characterization: mass of 42.8 kDa after removal of the signal peptide. The apparent molecular mass of APO-1-hFc is approximately 35-70 kDa due to glycosylation.Tag :C-Human Fc tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
