Human MSR1 Protein; His Tag
Product Sizes
50 µg
£621.00
32-18318-50UG
100 µg
£731.00
32-18318-100UG
About this Product
- SKU:
- 32-18318
- Additional Names:
- SRA;SR-A;CD204;SR-AI;phSR1;phSR2;SCARA1;SR-AII;SR-AIII
- Extra Details:
- Description :Recombinant human MSR1 Protein with N-terminal6Ã-His tagBackground: This gene encodes the class A macrophage scavenger receptors; which include three different types (1; 2; 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis; Alzheimer's disease; and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum; making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed; indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq; Jul 2008]Description: Recombinant human MSR1 Protein with N-terminal6Ã-His tagMolecular Characterization:6Ã-His tag MSR1(Lys77-Leu451)Molecular Weight :The protein has a predicted molecular mass of 42.1 kDa after removal of the signal peptide.Tag :N-6×His Tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
