Human IL4 Protein; His Tag
Product Sizes
50 µg
£621.00
32-18278-50UG
100 µg
£731.00
32-18278-100UG
About this Product
- SKU:
- 32-18278
- Additional Names:
- BSF1;BCGF1;BSF-1;BCGF-1;IL-4
- Extra Details:
- Description :Recombinant Human IL4 Protein with C-terminal 6XHis tag Background : The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13; which may contribute to many overlapping functions of this cytokine and IL13. STAT6; a signal transducer and activator of transcription; has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene; IL3; IL5; IL13; and CSF2 form a cytokine gene cluster on chromosome 5q; with this gene particularly close to IL13. This gene; IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair; counterbalancing the effects of proinflammatory type 1 cytokines; however; it also promotes allergic airway inflammation. Moreover; IL-4; a type 2 cytokine; mediates and regulates a variety of human host responses such as allergic; anti-parasitic; wound healing; and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response; IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients; but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Molecular Characterization: mass of 15.8 kDa after removal of the signal peptide. The apparent molecular mass of IL4-His is approximately 15-25 kDa due to glycosylation. Tag :C-6XHis Tag
- Host:
- HEK293
- Purification:
- The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
